Scars are areas of fibrous tissue (fibrosis) that replace normal skin after injury/wound healing. A scar results from the biological process of wound repair in the skin and other tissues of the body. Therefore, scarring is a natural part of the healing process.
Scar tissue is composed of the same protein ( collagen) as the tissue that it replaces. However- the fiber composition of the protein is different. Instead of a “basket-weave” formation of the collagen fibers- found in normal tissue- the collagen cross-links and forms a pronounced single direction alignment. This collagen scar tissue alignment is usually inferior in functional quality as compared to the normal collagen “random” alignment. Scars in the skin are less resistant to UV light/radiation and remain weaker in composition. Since sweat glands and hair follicles do not grown back in those areas, they tend to incur a significantly higher rate of irritation.
A treatment regimen that begins as the scar is forming and continues for many months is the best method for reducing scar tissue.
Levocetirizine is an antihistamine that suppresses both stimulation in keloid strains and collagen synthesis of fibroblasts. It inhibits the deposition and synthesis of collagen by suppressing the release of TGF-beta-1 from fibroblasts.
Pentoxifyline is a methylxanthine derivative with therapeutic use as an antifibrotic agent by inhibiting the production of collagen and reducing the proliferation of fibroblasts in hypertrophic scars.
Prilocaine is used as a local anesthetic.
Verapamil is a calcium channel blocker which stimulates pro-collagenase synthesis in keloids and hypertrophic scars.
One Stop Rx scar therapy creams are formulated in SaltStable LS cream base. SaltStable LS is an elegant, highly moisturizing cream formula with excellent penetrating properties. It is appealing for both pharmaceutical and cosmetic purposes.
Contact your One Stop Rx representative or pharmacist for more information on how we can help your patients scar.