is a fibrotic tissue disorder which is characterized by the presence of excess collagen or fibrotic tissue. The most common symptoms of plantar fibromatosis are the dense, firm nodules that can be felt just under the skin on the bottom of the foot. The nodules are painful with standing or walking and do not resolve on their own. Cells known as fibroblasts are responsible for the production of the primary components of plantar fibromas such as collagen, fibronectin and glycosaminoglycans. Research has shown that the process by which these components are released out of the fibroblast requires calcium.
Diclofenac is a non-steroidal anti-inﬂammatory medication (NSAID). NSAID”s have been shown useful in treating plantar ﬁbromatosis but are often limited on the duration of use orally due to gastrointestinal or cardiovascular effects. Topical formulation allows for consistent use without these concerns.
Baclofen , a GABA derivative, is used to reduce spasms and cramping.
Bupivacaine acts as a local anesthetic.
Mometasone is a glucocorticosteroid used to reduce inﬂammation. Steroids have been used in various formulations and vehicles to treat plantar ﬁbromatosis.
Topical creams allow for noninvasive treatment, decreased systemic effects, and consistent, constant treatment at the direct site of the fibroma.
One Stop Rx can provide a plantar fibromatosis pain cream preparation that can be individualized to fit a patient’s needs.