Neuropathic Pain


Nerve pain. One word: Debilitating. The symptoms are difficult to treat and can significantly affect a patient’s quality of life. Studies have shown that people with nerve pain have the highest rates of sleep problems, anxiety, and depression. Nerve pain is caused by lesions or deformities of the nerve. Symptoms may include burning, tingling, numbness, and shocks of electricity.

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Ketamine acts as an NMDA antagonist and is used as an analgesic, while Gabapentin, a glutamate antagonist, has been widely used for neuropathy. Together they mitigate glutaminergic calcium influx more effectively than either agent alone.

Clonidine potentiates analgesic affects but is limited orally by its effects on blood pres­sure. Topically it also enhances the effects of other analgesics in the formula.

Amitriptyline interferes with the way the nerve impulses are transmitted, reducing pain sensation.

Mefenamic Acid is an NSAID found to help reduce nerve pain while Bupivacaine is used as a local anesthetic.

Treating nerve pain can sometimes be difficult. Oral medications, although effective, have many undesirable side effects. Oral NSAIDS, painkillers, and inhibitors of neuron excitation can be effective for treating symptoms. However, they are not ideal for many patients due to negative systemic side effect profiles that include GI distress/discomfort, lethargy/sedation and cardiovascular events.

Topical preparations effectively treat pain at the source with limited systemic absorption which can improve patient adherence and decrease dependence on oral medications while maximizing therapeutic outcomes. One Stop Pharmacy can provide a neuro pain cream option that can be individualized to fit a patient’s needs.